Accurate Mass Spectrometry Software Solutions
Cerno develops and publishes award-winning mass spectrometry calibration and analysis software
DEMO YOUR DATACerno’s software not only enables formula determination at unit mass resolution (single or triple quad) with 100x improvement in mass accuracy (CLIPS), a capability typically reserved only for HiRes MS systems, but also improves formula ID at HiRes by 20x through the Spectral Accuracy concept (sCLIPS). These dramatic results are enabled through the patented TrueCal™ calibration process and validated by hundreds of publications and thousands of satisfied users across the world.
For unit resolution quadrupoles:
- 100x better mass accuracy
- up to 99.9% Spectral Accuracy
- Confident elemental composition determination
- Mixture deconvolution for isotope analysis and large molecule deconvolution
For high resolution TOF, Orbitrap, FT ICR:
- Self-calibrates peak shape without standards for exact isotope modeling
- Eliminates 95-99% of incorrect formulas with high spectral accuracy
- Quantitative measurements for biologics degradation analysis
Extractables and Leachables Event: Sponsored by Cerno Bioscience
Technology Spotlight: Software Automation for E&L at 9:05 Thursday November 2, 2023:
Improving the E&L GC/MS Workflow with Software Automation.
Benjamin Johnson, Manager, GC/VOC Lab, NSF International
(Co-Authors: Don Kuehl & Yongdong Wang, Cerno Bioscience)
MassWorks TrueCal™ calibration technology
MassWorks TrueCal™ calibration technology provides advantages for both high and low resolution instruments.

Figure shows an almost perfect match (Spectral Accuracy) between a calibrated single quad and the corresponding “True” calculated MS using the CLIPS search.

Figure shows excellent spectral accuracy match for confident formula ID on a high resolution TOF instrument using sCLIPS search.
Proper mass spec calibration
Proper mass spec calibration also means that complex mixture deconvolution of overlapping and interfering ions is easy and provides the most accurate quantitative results.

Figure shows the accurate quantitative analysis of 7 component mixture of a C13 radio labeled pharmaceutical using a quadrupole instrument.

Figure shows the ability to detect and deconvolve modified products (glycan conjugates 0 – 10) of a large molecule intact protein (by Maldi) (see ASMS poster). This type of analysis is not possible by other means!
Powerful GC/MS Analysis Software – GC/ID™
GC/ID is the first major breakthrough in GC/MS in decades
GC/ID is a fully automated compound identification application that offers new levels of accuracy and confidence in GC/MS qualitative and semi-quantitative analysis. Based on the new MassWorks Rx configurable platform, GC/ID offers powerful new capabilities to GC/MS including:
- Uses the industry standard NIST search engine
- Retention Index (RI) matching provides unsurpassed unknown ID confidence
- Accurate mass analysis of molecular/fragment ions for confident compound ID
- Magic Highlighter indicates at a glance the correct match by combining search, RI, and formula ID
The software that started it all… MassWorks™
Easy-to-use post acquisition software | Achieve high Mass Accuracy and high Spectral Accuracy
With over a dozen patents and 1000’s of users, the award winning MassWorks established the performance benchmark for “True” mass spec calibration. MassWorks is a Windows based desktop software that works with most MS vendor instruments by directly reading the data files making the powerful calibration and analysis technologies available to both nominal and high resolution instruments.
LEARN MOREFeatured technologies
Cerno Introduces SAMMI
Cerno calibration technology provides a new innovative approach to large molecule analysis for peptides, proteins, oligonucleotides, and any multiply charged molecule.
READ MORENew! GC/ID™ 4.0!
Riding on the success of V3 with groundbreaking features including Auto RI™ and Magic Highlighter™, V4 adds revolutionary SMD peak deconvolution along with a host of improvements and upgrades.
WATCH WEBINARGC/MS Automated Retention Index
Watch the following webinar GC/MS analysis using automated retention index and library search. Improving the confidence of unknown identification in GC/MA with Don Kuehl.
WATCH WEBINARMassWorks Version 6.1
MassWorks 6.1 is still the easy-to-use post acquisition software package that utilizes Cerno’s patented TrueCal™ technology to achieve high mass accuracy and high Spectral Accuracy.
LEARN MORENIST and Wiley MS libraries
Cerno is an authorized distributor of all NIST and Wiley MS libraries making over 1,000,000 unique compounds available at great prices! Contact us for a quote for new libraries or upgrades. New! NIST23 is now available in Agilent PBM format.
LEARN MOREWhat is Spectral Accuracy
Learn how the Cerno patented TrueCal mass spec calibration works and why it is such an enabling technology for unit resolution mass spectrometers.
WATCH VIDEOThe concept of Spectral Accuracy for Mass Spectrometry
With the introduction of spectral accuracy, a companion concept to the better known mass accuracy, new capabilities previously thought unfeasible can now be enabled for MS.
LEARN MORE