The process of drug metabolism refers to how living organisms break down drugs using specialized enzymatic systems. This can happen through various methods such as oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization. The ultimate goal is to make the drug easier to excrete. These enzymes can be found in many tissues but are typically more concentrated in the liver. Xenobiotic metabolism is the modification of the chemical structure of compounds foreign to an organism’s normal biochemistry, like drugs or poisons. Prodrugs, which are administered in an inactive form, are metabolized into an active form.
Please find below our supporting resources:
- RCMSDon Kuehl, Yongdong Wang, Peter L. Wang, Dawei Zhou
- Journal of the American Chemical SocietyCian Kingston , Michael A. Wallace, Alban J. Allentoff, Justine N. deGruyter , Jason S. Chen, Sharon X. Gong, Samuel Bonacorsi, Jr., and Phil S. Baran (see supporting information)
- WuXiAppTecD. Zhou, J. Zhao, P. L. Wang, Y. Wang, D. Kuehl
- CernoD.Kuehl,Y.Wang Appnote113
- XenoBioticJ.Zhao,P.Wang,D.Zhou,Z.Fang,M.Gu,Y.Wang ASMS2016
- Investigation of complex isotope patterns of 13C-labeled plant metabolites by Mass Spectral DeconvolutionMichigan State UniversityZ.Wang,A.Jones,Y.Wang ASMS2015