Cerno develops and publishes award-winning mass spectrometry calibration and analysis software which not only enables formula determination at unit mass resolution (single or triple quad) with 100x improvement in mass accuracy (CLIPS), a capability typically reserved only for HiRes MS systems, but also improves formula ID at HiRes by 20x through the Spectral Accuracy concept (sCLIPS). These dramatic results are enabled through the patented TrueCal™ calibration process and validated by hundreds of publications and thousands of satisfied users across the world.
For unit resolution quadrupoles:
- 100x better mass accuracy
- up to 99.9% Spectral Accuracy
- Confident elemental composition determination
- Mixture deconvolution for isotope analysis and large molecule deconvolution
For high resolution TOF, Orbitrap, FT ICR:
- Self-calibrates peak shape without standards for exact isotope modeling
- Eliminates 95-99% of incorrect formulas with high spectral accuracy
- Quantitative measurements for biologics degradation analysis
MassWorks TrueCal™ calibration technology provides advantages for both high and low resolution instruments. The above left figure shows an almost perfect match (Spectral Accuracy) between a calibrated single quad and the corresponding “True” calculated MS using the CLIPS search. The figure on the right shows excellent spectral accuracy match for confident formula ID on a high resolution TOF instrument using sCLIPS search.
Proper mass spec calibration also means that complex mixture deconvolution of overlapping and interfering ions is easy and provides the most accurate quantitative results. The top figure shows the accurate quantitative analysis of 7 component mixture of a C13 radio labeled pharmacutical using a quadrupole instrument. The bottom figure shows the ability to detect and deconvolve modified products (glycan conjugates 0 – 10) of a large molecule intact protein (by Maldi) (see ASMS poster). This type of analysis is not possible by other means!
Powerful GC/MS Analysis Software
GC/ID is the first major breakthrough in GC/MS in decades
GC/ID is a fully automated compound identification application that offers new levels of accuracy and confidence in GC/MS qualitative and semi-quantitative analysis. Based on the new MassWorks Rx configurable platform, GC/ID offers powerful new capabilities to GC/MS including:
- Uses the industry standard NIST search engine
- Retention Index (RI) matching provides unsurpassed unknown ID confidence
- Accurate mass analysis of molecular/fragment ions for confident compound ID
- Magic Highlighter indicates at a glance the correct match by combining search, RI, and formula ID
Learn more about GC/ID here.
The software that started it all…
Easy-to-use post acquisition software | Achieve high Mass Accuracy and high Spectral Accuracy
With over a dozen patents and 1000’s of users, the award winning MassWorks established the performance benchmark for “True” mass spec calibration. MassWorks is a Windows based desktop software that works with most MS vendor instruments by directly reading the data files making the powerful calibration and analysis technologies available to both nominal and high resolution instruments. Learn more about it here.
Cerno is an authorized distributor of NIST and Wiley MS libraries and MS software
Get your MS libraries for use with MassWorks Rx GC/ID or stand alone for any MS system. In addition to EI data libraries are available for MS/MS instruments. Most libraries also include extensive meta data including retention time index (used automatically by GC/ID), and chemical structures.
Cerno Introduces SAMMI
Cerno calibration technology provides a new innovative approach to large molecule analysis for peptides, proteins, oligonucleotides, and any multiply charged molecule. Read more about SAMMI.
New! GC/ID™ 4.0!
Riding on the success of V3 with groundbreaking features including Auto RI™ and Magic Highlighter™, V4 adds revolutionary SMD peak deconvolution along with a host of improvements and upgrades. To learn more about GC/ID check out the brochure or watch the March 22 Webinar.
Watch C&EN Webinar on GC/MS Automated Retention Index
MassWorks Version 6.1 has been released!
Read all About it.
Cerno is an authorized distributor of all NIST and Wiley MS libraries making over 1,000,000 unique compounds available at great prices! Contact us for a quote for new libraries or upgrades. New! NIST23 is now available in Agilent PBM format.
View our recent mini-webinar Series:
Mass Spectral Accuracy: What is it, and Why is it so Important?
Differentiating the Loss of 43Da EI Fragments (C3H7 or CH3C=O) with Single Quad GC/MS
