Join Hands with Academic Institutions through CAP!

With Cerno MassWorks at your fingertips, you’ll experience a unique MS application that allows you to collaborate and learn alongside esteemed professors/mentors and fellow students. This interactive, data-driven process will not only enhance your understanding of MS but also provide you with the opportunity to make exciting discoveries along the way.

Testimonial | University of West Florida

“Collaborating with Cerno and my entire instrumental analysis lecture lab class this year, we utilized new technology for research and presented our findings at conferences. Our goal is to make a meaningful impact on aspiring students. Together, within the scientific community, we aim to provide research software for students to enhance their learning.” – Karen W. Barnes, Ph.D. (She/Her), Lecturer, Chemistry | CURE Fellow. University of West Florida, Coordinator, General Chemistry Laboratories

Did you know? MassWorks is an acceptable standard!

Cerno’s MassWorks research software is now accepted for organic synthesis confirmation in ACS journal publications, including JOC! Since the introduction of its innovative MS calibration and analysis software, Cerno Bioscience has received many similar questions from potential users, especially academic users, on the acceptability of MassWorks accurate mass results for publication in JOC-type journals, even with data from unit mass resolution GC/MS or LC/MS systems.

Cerno has closely followed the evolution of the JOC requirement for compound identification over the years, from the initial 5ppm mass accuracy with HRMS, the +/-3mDa mass accuracy without explicitly requiring HRMS, to the current “MS accurate mass (historically called HRMS or exact mass) data”. Read more below…

Accurate Mass Results Acceptable for Publication in the Journal of Organic Chemistry (JOC)
Click here to view PDF documentation: MassWorks Research Software

Cerno’s Application Notes

Spectral Accuracy vs Mass Accuracy or Both?

What is Spectral Accuracy? While Mass Accuracy is a measure of a single point m/z error between a given isotope peak and its theoretical (exact) mass, Spectral Accuracy is a measure of the spectral congruence between the whole measured mass spectral profile and the theoretically calculated true mass spectrum for a given elemental composition.  Combining both Mass Accuracy and Spectral Accuracy, one obtains the much more powerful Effective Mass Accuracy (EMA).

• Spectral Accuracy Defined
• Learn About Spectral Accuracy (Analytical Chemistry Feature Article)
• Calibration for Both Mass and Spectral Accuracy (Video)
• Spectral Accuracy to Differentiate Elemental Composition (Animation)
• EMA – Effective Mass Accuracy poster (Poster)

Confirmation of Organic Synthesis in ACS Journal Publications

• MassWorks for Education and University Research 
• ACS Journal Catalysis: A Cross-Coupling Approach to Amide Bond Formation from Esters
• ACS Journal JACS: Palladium-Catalyzed Suzuki-Miyaura Coupling of Aryl Esters
• ACS Journal Org. Lett.: eFluorination Using Cheap and Readily Available Tetrafluoroborate Salts

SAMMI Spectrally Accurate Modeling of Multiply charged Ions

An entirely different take on multiple charge deconvolution through Spectral Accuracy:

• • SAMMI webpage
  • Brochure
  • SAMMI: A Direct Computational Approach to the Analysis of Multiply Charged Biomolecules and Their Modifications with Electrospray Mass Spectrometry
  • Full Spectral Confirmation of Multiply Charged RNA Molecules and Their Modifications with a Single Quadrupole LC/MS System

Labelled Isotope Analysis

• How MassWorks mixture analysis feature could be used to separate out and quantify differently labeled compounds
  Spectrally accurate quantitative analysis of isotope-labeled compounds
• Metabolic flux analysis (Michigan State University) Investigation of complex isotope patterns of 13C-labeled plant metabolites by Mass Spectral Deconvolution
• Deuteration analysis (Boston College): Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry
• Hydrogen-Deuterium Exchange (HDE)
  • Stanford University, JACS,  Rapid Hydrogen−Deuterium Exchange in Liquid Droplets (see supporting information)
  • A Novel Approach for Quantitation of Hydrogen Deuterium Exchanged Peptides to Reveal Full Distribution of the Exchanged Species at Various Time Points