Join our Scientific Community with CAP!

At Cerno, you’ll not only experience a comprehensive program but also a one-of-a-kind chance to collaborate with esteemed professors, fellow students, and other peer mentors. This provides an enriching opportunity to engage with a diverse and knowledgeable scientific community.

Testimonial | University of West Florida

“Collaborating with Cerno and my entire instrumental analysis lecture lab class this year, we utilized new technology for research and presented our findings at conferences. Our goal is to make a meaningful impact on aspiring students. Together, within the scientific community, we aim to provide research software for students to enhance their learning.” – Karen W. Barnes, Ph.D. (She/Her), Lecturer, Chemistry | CURE Fellow. University of West Florida, Coordinator, General Chemistry Laboratories

Did you know? MassWorks is an acceptable standard!

Cerno’s MassWorks research software are now acceptable for organic synthesis confirmation in ACS journal publications such as JOC! Since the introduction of its innovative MS calibration and analysis software, Cerno Bioscience has received many similar questions from potential users, especially academic users, on the acceptability of MassWorks accurate mass results for publication in JOC-type journals, even with data from unit mass resolution GC/MS or LC/MS systems.

Cerno has closely followed the evolution of the JOC requirement for compound identification over the years, from the initial 5ppm mass accuracy with HRMS, the +/-3mDa mass accuracy without explicitly requiring HRMS, to the current “MS accurate mass (historically called HRMS or exact mass) data”. Read more below…

Accurate Mass Results Acceptable for Publication in the Journal of Organic Chemistry (JOC)
Click here to view PDF documentation: MassWorks Research Software

Cerno’s Application Notes

Spectral Accuracy versus and in combination with Mass Accuracy

What is Spectral Accuracy? In the context of mass spectrometry, spectral accuracy refers to the ability of an instrument to accurately measure the mass-to-charge ratio (m/z) of ions, which is essential for identifying the chemical composition of a sample. High spectral accuracy is achieved by calibrating instruments to obtain high mass accuracy, which is typically expressed in parts per million (ppm). Spectral accuracy is an important measure of the accuracy of a spectral method in approximating the solution of a differential equation, and it is also a critical aspect of mass spectrometry, where it refers to the ability of an instrument to accurately measure the mass-to-charge ratio of ions.

• Spectral Accuracy Defined
• Learn About Spectral Accuracy (Analytical Chemistry Feature Article)
• Cerno Calibration Tutorial (Video)
• Spectral Accuracy to Differentiate Elemental Composition (Animation)

Confirmation of Organic Synthesis for ACS Journal Publications

• MassWorks for Education and University Research 
• MassWorks results in ACS Journal: A Cross-Coupling Approach to Amide Bond Formation from Esters
• ACS Catalysis Asymmetric Synthesis of Rauhut-Currier Adducts by an Asymmetric Frustrated Vinylogous Mukaiyama Reaction
• JACS Palladium-Catalyzed Suzuki-Miyaura Coupling of Aryl Esters

SAMMI for Spectrally Accurate Modeling of Multiply-charged Ions

An entirely different take on multiple charge deconvolution through Spectral Accuracy:

• SAMMI webpage
• Brochure
• SAMMI: A Direct Computational Approach to the Analysis of Multiply Charged Biomolecules and Their Modifications with Electrospray Mass Spectrometry
• Full Spectral Confirmation of Multiply Charged RNA Molecules and Their Modifications with a Single Quadrupole LC/MS System
• ASMS We 480 Accurate mass spectral deconvolution of multiply-charged oligonucleotides

Labelled Isotope Analysis

• How MassWorks mixture analysis feature could be used to separate out and quantify differently labeled compounds
  Spectrally accurate quantitative analysis of isotope-labeled compounds
• Metabolic flux analysis: Michigan State University Investigation of complex isotope patterns of 13C-labeled plant metabolites by Mass Spectral Deconvolution
• Deuteration analysis: Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry, Boston College.
• Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry, Haukeland University Hospital, Epizyme Inc, Institut Laue-Langevin
• Hydrogen-Deuterium Exchange (HDE)
  • Small molecule kinetics: JACS Rapid Hydrogen−Deuterium Exchange in Liquid Droplets
  • Bio-molecules: A Novel Approach for Quantitation of Hydrogen Deuterium Exchanged Peptides to Reveal Full Distribution of the Exchanged Species at Various Time Points