Drug Discovery

In early drug discovery open access LC/MS is widely used for compound confirmation/identification of possible drug candidates, intermediates, and other products. Enabled by unique instrument line shape calibration technology, open access LC/MS quadrupole systems can routinely achieve high mass accuracy and high spectral accuracy for the purpose of compound confirmation/identification. However, this great performance can be compromised by highly saturated MS signal caused by overly high concentration of samples. We have worked out a solution to provide open access MS users with useful results even with any data containing saturated signal and a suggested sample dilution for best possible formula confirmation/identification results.

Spectral Accuracy of a Saturated Peak at Different Scans

Please find our additional resources:

ASMS We 480 Accurate mass spectral deconvolution of multiply-charged oligonucleotides
Agilent, Cerno Bioscience at ASMS 2024Patrick M Batoon, Lee Bertram; Yongdong Wang
Automatic Dilution Factor Determination for Quadrupole LC/MS and Its Application to Open Access Formula ID in Drug Discovery
AstraZenecaH.Xu,Y.Wang,S.Tentarelli ASMS2012
Spectral accuracy of a new hybrid quadrupole time-of-flight mass spectrometer: application to ranking small molecule elemental compositions
Rapid Commun. Mass Spectrom.Wei Jiang and John C. L. Erve*
Evaluation of Accurate Mass and Dynamic Range Capabilities of Low and High-Resolution Instrumentation in Compound Identification In Drug Discovery
AstraZenecaV.Capka,S.Tentarelli ASMS2010
Feasibility and Reliability of Low and High-Resolution MS Approaches for Accurate Mass and Molecular Formula Determination in Drug Discovery.
AstraZenecaV.Capka,M.Gu ASMS2009
Quantitative analysis of antiretroviral drugs by MALDI-TOF mass spectrometry
Erasmus MCJ. vanKampen, P. Burgers, R.deGroot, T.Luider ASMS2005

Search