Cerno develops and publishes award-winning mass spectrometry calibration and analysis software which not only enables formula determination at unit mass resolution (single or triple quad) with 100x improvement in mass accuracy (CLIPS), a capability typically reserved only for HiRes MS systems, but also improves formula ID at HiRes by 20x through the Spectral Accuracy concept (sCLIPS). These dramatic results are enabled through the patented TrueCal™ calibration process and validated by hundreds of publications and thousands or satisfied users across the world.

For unit resolution quadrupoles:

100x better mass accuracy
up to 99.9% Spectral Accuracy
Confident elemental composition determination
Mixture deconvolution for isotope analysis and large molecule degredation

For high resolution TOF, Orbitrap, FT ICR:

Self-calibrates peak shape without standards for exact isotope modeling
Eliminates 95-99% of incorrect formulas with high spectral accuracy
Quantitative measurements for biologics degradation analysis

MassWorks TrueCal™ calibration technology provides advantages for both high and low resolution instruments. The above left figure shows an almost perfect match (Spectral Accuracy) between a calibrated single quad and the corresponding “True” calculated MS using the CLIPS search. The figure on the right shows excellent spectral accuracy match for confident formula ID on a high resolution TOF instrument using sCLIPS search.

Proper mass spec calibration also means that complex mixture deconvolution of overlapping and interfering ions is easy and provides the most accurate quantitative results. The top figure shows the accurate quantitative analysis of 7 component mixture of a C13 radio labeled pharmacutical using a quadrupole instrument. The bottom figure shows the ability to detect and deconvolve modified products (glycan conjugates 0 – 10) of a large molecule intact protein (by Maldi) (see ASMS poster). This type of analysis is not possible by other means!

Introducing…

GC/ID is a fully automated compound identification application that offers new levels of accuracy and confidence in GC/MS qualitative analysis. Based on the powerful new MassWorks Rx configurable platform, GC/ID offers powerful new capabilities to GC/MS including:

Deconvolves unresolved peaks with 10x the sensitivity of conventional methods
Accurate mass search of NIST libraries with retention time index
Molecular ion and mass fragment formula ID for unknown compound ID
Report generation and LIMS integration

Learn more about GC/ID here.

The software that started it all…

With over a dozen patents and 1000’s of users, the award winning MassWorks established the performance benchmark for “True” mass spec calibration. MassWorks is a Windows based desktop software that works with most MS vendor instruments by directly reading the data files making the powerful calibration and analysis technologies available to both nominal and high resolution instruments. Learn more about it here.

Cerno is an authorized distributor of NIST and Wiley MS libraries and MS software

Get your MS libraries for use with MassWorks Rx GC/ID or stand alone for any MS system. In addition to EI data libraries are available for MS/MS instruments. Most libraries also include extensive meta data including retention time index (used automatically by GC/ID), and chemical structures.

Cerno is an authorized distributor of all NIST and Wiley MS libraries making over 1,000,000 unique compounds available at great prices! Contact us for a quote for new libraries or upgrades. New! NIST20 is now available in Agilent PBM format.

View are recent mini-webinar Series:

Mass Spectral Accuracy: What is it, and Why is it so Important?

Improving and Automating GC/MS Compound ID on Quadruple MS using Accurate Mass, Spectral Accuracy, Retention Index, and Conventional Search

Differentiating the Loss of 43Da EI Fragments (C3H7 or CH3C=O) with Single Quad GC/MS

Visit Cerno at booth 614 at ASMS 2021 in Philadelphia, PA Oct 31 – Nov 4 2021. (More)

GC/ID Version 2 has been released!
Read about the great new features and improvements including NIST20 and Wiley 12 support with full Retention Index coverage.

MassWorks Version 6.1 has been released!
Read all About it.

User Testimonials

"I have tested and used the MassWorks software since the summer of 2007. The main purpose for me is using its formula ID feature to confirm the GC/MS NIST library search results for unknown chemical substance identification especially when the [NIST] search match values are similar for more than one compounds. The software is relatively simple to use and most times provides the #1 match for our testing chemicals with more than 200 compounds in a variety of chemical groups."
User from a United States Government Environmental Lab
"The program is very easy to learn, it literally took minutes to get the first exciting results. On our 10 year-old triple quad, we manage to achieve mass accuracies of 10 ppm or better, routinely! It has become an integral part of our characterization pipeline for newly synthesized compounds."
University of ViennaDr. Alexander Leitner
"Your software [MassWorks] continues to amaze. Your first candidate is indeed the unknown -- atranorin [LC/MS]. I'd like to get the software that works with both our Shimadzu GC-single quad and our Shimadzu LC-triple quad."
Oberlin CollegeDr. Robert Thompson
"Starting a little bit "speechless" from our side your Presentation helped really changing our mindset, from "unbelieving" into "believer". After this Test with a sample taken from real life with real interferences my colleagues and I fully agree that MassWorks is indeed a powerful tool for advanced GC/MS analysis. We found that MassWorks is really a "must have" product for us..."
Researcher from a large German chemical company
"The ability to provide the elemental identification of unknown compounds on a routine basis by any scientist is now within one's reach." - Click here to read full presentation
Eli LillyJ.Mick,T.Gillespie ASMS2007
"MassWorks has proven itself on our GC/MSD system for accurate mass measurements and unknown formula ID. When applied to LC/MSD, it also worked amazingly well to provide accurate mass results for the identification or confirmation of small molecule organic compounds"
Universidad Autónoma de MadridDr. José Alemán