Cerno develops and publishes award-winning mass spectrometry calibration and analysis software which not only enables formula determination at unit mass resolution (single or triple quad) with 100x improvement in mass accuracy (CLIPS), a capability typically reserved only for HiRes MS systems, but also improves formula ID at HiRes by 20x through the Spectral Accuracy concept (sCLIPS). These dramatic results are enabled through the patented TrueCal™ calibration process and validated by hundreds of publications and thousands or satisfied users across the world.

For unit resolution quadrupoles:

100x better mass accuracy
up to 99.9% Spectral Accuracy
Confident elemental composition determination
Mixture deconvolution for isotope analysis and large molecule degredation

For high resolution TOF, Orbitrap, FT ICR:

Self-calibrates peak shape without standards for exact isotope modeling
Eliminates 95-99% of incorrect formulas with high spectral accuracy
Quantitative measurements for biologics degradation analysis

MassWorks TrueCal™ calibration technology provides advantages for both high and low resolution instruments. The above left figure shows an almost perfect match (Spectral Accuracy) between a calibrated single quad and the corresponding “True” calculated MS using the CLIPS search. The figure on the right shows excellent spectral accuracy match for confident formula ID on a high resolution TOF instrument using sCLIPS search.

Proper mass spec calibration also means that complex mixture deconvolution of overlapping and interfering ions is easy and provides the most accurate quantitative results. The top figure shows the accurate quantitative analysis of 7 component mixture of a C13 radio labeled pharmacutical using a quadrupole instrument. The bottom figure shows the ability to detect and deconvolve modified products (glycan conjugates 0 – 10) of a large molecule intact protein (by Maldi) (see ASMS poster). This type of analysis is not possible by other means!

Powerful GC/MS Analysis Software

GC/ID is a fully automated compound identification application that offers new levels of accuracy and confidence in GC/MS qualitative analysis. Based on the powerful new MassWorks Rx configurable platform, GC/ID offers powerful new capabilities to GC/MS including:

Deconvolves unresolved peaks with 10x the sensitivity of conventional methods
Accurate mass search of NIST libraries with retention time index
Molecular ion and mass fragment formula ID for unknown compound ID
Report generation and LIMS integration

Learn more about GC/ID here.

The software that started it all…

With over a dozen patents and 1000’s of users, the award winning MassWorks established the performance benchmark for “True” mass spec calibration. MassWorks is a Windows based desktop software that works with most MS vendor instruments by directly reading the data files making the powerful calibration and analysis technologies available to both nominal and high resolution instruments. Learn more about it here.

Cerno is an authorized distributor of NIST and Wiley MS libraries and MS software

Get your MS libraries for use with MassWorks Rx GC/ID or stand alone for any MS system. In addition to EI data libraries are available for MS/MS instruments. Most libraries also include extensive meta data including retention time index (used automatically by GC/ID), and chemical structures.

New! GC/ID™ 3.0 !

Read about the amazing new features including Auto RI™ and Magic Highlighter™ or watch the March 22 Webinar to learn. GC/ID V3 Press Release.

Watch C&EN Webinar on GC/MS Automated Retention Index

MassWorks Version 6.1 has been released!
Read all About it.

Cerno is an authorized distributor of all NIST and Wiley MS libraries making over 1,000,000 unique compounds available at great prices! Contact us for a quote for new libraries or upgrades. New! NIST20 is now available in Agilent PBM format.

View are recent mini-webinar Series:

Mass Spectral Accuracy: What is it, and Why is it so Important?

Improving and Automating GC/MS Compound ID on Quadruple MS using Accurate Mass, Spectral Accuracy, Retention Index, and Conventional Search

Differentiating the Loss of 43Da EI Fragments (C3H7 or CH3C=O) with Single Quad GC/MS

User Testimonials

"Congratulations!! Once more I are am deeply impressed by sClips. In both cases you are right with the top no. 1 [formula]!! Additionally, I find it fantastic that you do not need a calibration standard for higher resolving mass specs, by “just” looking at the isotope signals."- Communication from blind sample evaluation on a Leco LC-TOF
Universität Hohenheim, GermanyProf. Dr. Wolfgang Schwack
"The use of exact isotope modeling [with MassWorks] is key to unique formula ID [with FT-ICR] and profile mode peakshape calibration is needed to achieve the required Spectral Accuracy." - Click here to read full presentation
Boehringer IngelheimS.Pennino,F.Qiu,Y.Wang ASMS2008
"MassWorks has proven itself on our GC/MSD system for accurate mass measurements and unknown formula ID. When applied to LC/MSD, it also worked amazingly well to provide accurate mass results for the identification or confirmation of small molecule organic compounds"
Universidad Autónoma de MadridDr. José Alemán
"Determining the elemental composition of pure materials at modest resolution typical of quads has never been routinely practiced – CLIPS brings that task very close to practice for the general user. It is not too much of a stretch to suggest CLIPS will enhance the confidence of TOF-based assignments as well, which may even challenge slower FTMS-based determinations."
User at a large midwest consumer products company
"Starting a little bit "speechless" from our side your Presentation helped really changing our mindset, from "unbelieving" into "believer". After this Test with a sample taken from real life with real interferences my colleagues and I fully agree that MassWorks is indeed a powerful tool for advanced GC/MS analysis. We found that MassWorks is really a "must have" product for us..."
Researcher from a large German chemical company
"The accurate mass profile extract ion chromatogram (AMPXIC) obtained through accurate mass measurement and isotope profile-mode filtering [performed with MassWorks] eliminated the false positive peaks observed using conventional XIC in the metabolite profile." - Click here to read full presentation
Wyeth ResearchM.Zhang,M.Gu,N.Kagen ASMS2008