MassWorks

MassWorks is an easy-to-use post acquisition software package that utilizes Cerno’s patented TrueCal™ technology to achieve high mass accuracy and high Spectral Accuracy on conventional mass spectrometers of unit mass resolution using the patented CLIPS formula search.  MassWorks sCLIPS and BestScan sCLIPS now also provide high spectral accuracy through exact line-shape calibration without the need for standards. MassWorks integrates the powerful TrueCal calibration technology to obtain up to 100X improvement in mass accuracy on unit resolution systems and up to 99.9% spectral accuracy on both high and unit resolution systems in a fast and versatile MS software application package. By combining novel calibration techniques with sound mathematical principles, Cerno methodologies can provide significant improvements to all types of MS data, both high and low resolution.

  • High mass accuracy on quadrupole GC or LC/MS (up to 5ppm)
  • Improved Spectral Accuracy on all systems (up to 99.9%)
  • Effective noise filtering (up to 3X)

MassWorks now includes sCLIPS and Best Scan sCLIPS, for improving formula ID on high resolution MS, and CLIPS, enabling formula ID on unit resolution GC or LC/MS single or triple quadrupoles.

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What users are saying about MassWorks: (Read All)

  • "Congratulations!! Once more I are am deeply impressed by sClips. In both cases you are right with the top no. 1 [formula]!! Additionally, I find it fantastic that you do not need a calibration standard for higher resolving mass specs, by “just” looking at the isotope signals."- Communication from blind sample evaluation on a Leco LC-TOF
    Universität Hohenheim, GermanyProf. Dr. Wolfgang Schwack
  • "MassWorks has proven itself on our GC/MSD system for accurate mass measurements and unknown formula ID.  When applied to LC/MSD, it also worked amazingly well to provide accurate mass results for the identification or confirmation of small molecule organic compounds"
    Universidad Autónoma de MadridDr. José Alemán
  • "With PFTBA calibration performed to each GC/MS run, mass accuracy better than 10mDa can be achieved and Spectral Accuracy of better than 99% can be achieved to help attain reliable formula determination. The mass calibration is stable after 11 days without significantly compromising formula determination. While mass calibration is more susceptible to time related variations, the Spectral Accuracy has been shown to be robust enough for formula determination after 19 days." -Click here to read full presentation
    Boehringer IngelheimJ.Mullis,F.Qiu,Y.Wang ASMS2008
  • "The use of exact isotope modeling [with MassWorks] is key to unique formula ID [with FT-ICR] and profile mode peakshape calibration is needed to achieve the required Spectral Accuracy."  - Click here to read full presentation
    Boehringer IngelheimS.Pennino,F.Qiu,Y.Wang ASMS2008
  • "The accurate mass profile extract ion chromatogram (AMPXIC) obtained through accurate mass measurement and isotope profile-mode filtering [performed with MassWorks] eliminated the false positive peaks observed using conventional XIC in the metabolite profile."  - Click here to read full presentation
    Wyeth ResearchM.Zhang,M.Gu,N.Kagen ASMS2008
  • "The program is very easy to learn, it literally took minutes to get the first exciting results. On our 10 year-old triple quad, we manage to achieve mass accuracies of 10 ppm or better, routinely! It has become an integral part of our characterization pipeline for newly synthesized compounds."
    University of ViennaDr. Alexander Leitner